pI: 9.735 |
Length (AA): 1131 |
MW (Da): 135114 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
267 | 536 | 2fds (A) | 24 | 324 | 18.00 | 0.000082 | 0.06 | 0.29 | -0.17 |
10 | 208 | 4tql (A) | 35 | 238 | 17.00 | 0.021 | 0.1 | 0.38155 | -0.9 |
10 | 218 | 4dph (B) | 59 | 340 | 34.00 | 0.041 | 0.22 | 0.0538922 | 1.35 |
47 | 305 | 4k1p (C) | 89 | 359 | 15.00 | 0.93 | 0.05 | 0.342601 | -0.33 |
103 | 627 | 3v0a (B) | 644 | 1156 | 26.00 | 0.0053 | 0.72 | 0.384291 | 1.54 |
33 | 281 | 4u0r (A) | 189 | 492 | 19.00 | 0.007 | 0.07 | 0.359797 | -0.49 |
42 | 433 | 3rqt (A) | 38 | 457 | 20.00 | 0.18 | 0.8 | 0.368567 | 0.91 |
61 | 233 | 2ap3 (A) | 14 | 194 | 20.00 | 0.21 | 0.08 | 0.351955 | -0.77 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, early ring, late ring, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, gametocyte, merozoite, early trophozoite, late trophozoite, Female Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128175)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G17690 | hypothetical protein |
Babesia bovis | BBOV_IV006620 | conserved hypothetical protein |
Brugia malayi | Bm1_23940 | Hypothetical 84.0 kDa protein in SGA1-KTR7 intergenic region |
Candida albicans | CaO19.9407 | similar to S. cerevisiae YIL091C |
Candida albicans | CaO19.1849 | similar to S. cerevisiae YIL091C |
Caenorhabditis elegans | CELE_Y41C4A.9 | Protein Y41C4A.9 |
Cryptosporidium hominis | Chro.70038 | hypothetical protein |
Cryptosporidium parvum | cgd7_250 | conserved protein |
Dictyostelium discoideum | DDB_G0289235 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3735 | CG3735 gene product from transcript CG3735-RB |
Echinococcus granulosus | EgrG_000837700 | digestive organ expansion factor |
Entamoeba histolytica | EHI_177370 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000837700 | digestive organ expansion factor |
Giardia lamblia | GL50803_6211 | Protein required for cell viability |
Homo sapiens | ENSG00000117597 | digestive organ expansion factor homolog (zebrafish) |
Leishmania braziliensis | LbrM.14.0420 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_140420.1 | Protein of unknown function (DUF1253), putative |
Leishmania infantum | LinJ.14.0420 | hypothetical protein, conserved |
Leishmania major | LmjF.14.0410 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.0410 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04023 | hypothetical protein |
Mus musculus | ENSMUSG00000016181 | digestive organ expansion factor homolog (zebrafish) |
Neospora caninum | NCLIV_035820 | hypothetical protein |
Oryza sativa | 4338320 | Os05g0295100 |
Onchocerca volvulus | OVOC7530 | Digestive organ expansion factor homolog |
Plasmodium berghei | PBANKA_1203400 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium falciparum | PF3D7_1005100 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium knowlesi | PKNH_0803800 | U3 small nucleolar RNA-associated protein 25, putative |
Plasmodium vivax | PVX_094450 | hypothetical protein, conserved |
Plasmodium yoelii | PY02979 | Drosophila melanogaster CG3735 gene product |
Saccharomyces cerevisiae | YIL091C | Utp25p |
Schistosoma japonicum | Sjp_0207720 | Digestive organ expansion factor homolog, putative |
Schistosoma japonicum | Sjp_0312610 | Digestive organ expansion factor homolog, putative |
Schistosoma mansoni | Smp_158840 | hypothetical protein |
Schmidtea mediterranea | mk4.000072.02 | Digestive organ expansion factor homolog |
Trypanosoma brucei gambiense | Tbg972.7.4900 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.4340 | Protein of unknown function (DUF1253), putative |
Trypanosoma congolense | TcIL3000_7_3530 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508857.100 | Protein of unknown function (DUF1253), putative |
Trypanosoma cruzi | TcCLB.504213.20 | Protein of unknown function (DUF1253), putative |
Toxoplasma gondii | TGME49_270960 | hypothetical protein |
Theileria parva | TP01_1213 | hypothetical protein |
Trichomonas vaginalis | TVAG_075430 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4340 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.4340 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y41C4A.9 | Caenorhabditis elegans | slow growth | wormbase |
YIL091C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_270960 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5